ICFRM is the major international conference and the leading platform for experts studying, developing and characterizing materials for fusion energy technologies. This biennial conference focuses on structural, functional, plasma facing and high heat flux materials including irradiation effects, materials engineering and technologies, and cutting-edge research. The ICFRM-21 will include plenary lectures, invited and contributed oral presentations, as well as poster sessions and tutorials. This event is organized by the Centro de Investigaciones, Energéticas, Medioambientales y Tecnológicas (CIEMAT), the IFMIF-DONES España, the University of Granada and the University of Alicante (UA), in collaboration with other Spanish institutions. As hosts, we are looking forward to welcoming you in Granada, Spain, while encouraging interesting and inspiring discussions, interactions and science.